The amount of debris or mold present in your system could certainly ratchet up the overall price. The cost of mildew removal is around $0.07-0.08 per square foot, on top of your initial cost, according to Blue Book. Removing these elements involves added time, special equipment and even special chemicals. In fact, you may be referred to a specialist if mildew and mold is too severe.
Heating, ventilation, and air conditioning (HVAC[1]) is the technology of indoor and vehicular environmental comfort. Its goal is to provide thermal comfort and acceptable indoor air quality. HVAC system design is a subdiscipline of mechanical engineering, based on the principles of thermodynamics, fluid mechanics and heat transfer. "Refrigeration" is sometimes added to the field's abbreviation, as HVAC&R or HVACR or "ventilation" is dropped, as in HACR (as in the designation of HACR-rated circuit breakers).
Our HVAC Ductwork Installation Cost Guide is the most comprehensive guide of its type. It fully explains the purpose of ductwork and all your options. Pricing is included for all duct types and plenums/drops too. Material and installation costs are listed. Ductwork cost varies greatly by the size and type of duct plus the complexity of the installation, but you can expect to pay $10.20 to $17.25 per linear foot installed.

I'm very glad that I found another guy to come replace the circuit board and put it away from the water, fix the water leak, and also find and fix another impending failure.  All of that was for much less than HVAC Service wanted to charge for repair or replacement. The other guy did a great repair, so I'm confident it will not break down again, but if it does, I will not call HVAC Service. Don't get suckered by their Yelp Deal.
Filtration systems -- A second-stage filter is sometimes inserted & used to remove particulates such as pets, smoking or cooking, as well as other odors, gases, and VOCs (volatile organic compounds). A HEPA filter is also available to remove spores, pollens, bacteria and lung-damaging particles. There are also systems that use ultraviolet (UV) light to protect against bacteria and germs.

Energy efficiency can be improved even more in central heating systems by introducing zoned heating. This allows a more granular application of heat, similar to non-central heating systems. Zones are controlled by multiple thermostats. In water heating systems the thermostats control zone valves, and in forced air systems they control zone dampers inside the vents which selectively block the flow of air. In this case, the control system is very critical to maintaining a proper temperature.
You may consider having your air ducts cleaned simply because it seems logical that air ducts will get dirty over time and should be occasionally cleaned. Provided that the cleaning is done properly, no evidence suggests that such cleaning would be detrimental. EPA does not recommend that the air ducts be cleaned routinely, but only as needed. EPA does, however, recommend that if you have a fuel burning furnace, stove or fireplace, they be inspected for proper functioning and serviced before each heating season to protect against carbon monoxide poisoning.