Engineers have pointed out some areas where efficiency of the existing hardware could be improved. For example, the fan blades used to move the air are usually stamped from sheet metal, an economical method of manufacture, but as a result they are not aerodynamically efficient. A well-designed blade could reduce electrical power required to move the air by a third.[28]
Despite such anecdotal experiences, there's no scientific evidence that regular residential air duct cleaning improves air quality, according to a 1997 brochure published by the Environmental Protection Agency. Laureen Burton, senior scientist in the EPA Indoor Environments Division, says that while the document is nearly two decades old, the science hasn't changed and the agency stands by its recommendations.
The answer to your question is most likely "Yes," but not defiitely. It depends on where the dust is coming from. Now, if your house is more than say, 12 years old then you likely do have leaks in your ducts that can let in insulation particles and dust from your attic. If this is the case then cleaning of the ducts-PROPER CLEANING, which like the article sas doess include EVERYTHING that the conditioned air passes through, such as your indoor evaporator coil and blower housing assembly-is definitely a good first step to getting that dust under control! Of course I highly recommend that you also have your ducts SEALED as well, or else you will have to repeat the cleaning some time down the line. As a 3rd step, consider an electronic air filter. I always thought they were a scam, personally, so I never bothered selling them to my clients. Then one day my manager sent me to install one for a senior couple in a mobile home. The wife had bad allergies, and her eyes were constantly watering and puffy and red. Well, I did a quality check 60 days later and she could not stop praising that air filter! Keep in mind that in a mobile home, duct seals are not as complete as those in other homes due to access issues.
They are also often harder to install. A proper location on the roof must be selected that can support the weight of the unit. Then a platform must be built and a drain pipe for the unit must be run along the roof to avoid problems with mold and corrosion. A crane must be used to lift the unit onto the roof while a team guides it into place and hooks it up.
There are many interesting comments from several informed individuals. The question that has not been answered is how do duct systems get dusty and dirty? As a RESNET Home Energy Rater, I perform pressure tests on homes and duct systems, and the one common thread is . . . most air delivery sytems have large amounts of air leakage. The solution is to seal the duct system, and pay particular attention to the return duct system and ductwork near the air handler (the 'blower'). As others have said, a captive (sealed) duct system with proper filter maintenance should be more then adequate for most occupants. For those who have allergy, asthma, or other breathing problems, a filter with a higher MERV rating (number should be listed on the package) or a HEPA filter are good choices. These filters will capture smaller particulates and should improve the indoor air quality. Again, make certain that the entire duct system is sealed, preferably with mastic, second choice UL-181 foil tape - never use cloth duct (also known as duck) tape.
To qualify for a tax credit from the federal government, you must save the manufacturer's certificate from your system. The IRS won't require the certificate at the time you file your federal tax forms, but they recommend keeping it with your records in case of an audit. It proves that you purchased a qualifying product. The government offers tax credits for:

My 48 yr old house (mine for the last 4 yrs) has considerable dust in the return plenum (fiber duct). I’m remodeling and recently re-sealed the return plenum AND the site-fabbed transition built when the new unit was installed, 2013. The return was leaky no doubt drawing musty, dusty air from the crawl space due to the Red-Neck fab & seal job! Pitiful craftsmanship! It took me 7 hours to fix the new transition piece. Anyway, the dust in the house is the same “color” as whats in the return duct and I’m getting way too much & too often in the house. I’ve also cleaned my coils, which were not that dirty.
You might also want to check your home for thermal insulation if you live in extreme heat or freezing temperatures. Insulation keeps the heat and cool air in your home, which can lead to a lower electric bill. If the heated or cool air leaks out, your system turns on more often. There are various types of insulation that you can install in your home and a home energy auditor can point out the best places for it in your house.
The most recognized standards for HVAC design are based on ASHRAE data. The most general of four volumes of the ASHRAE Handbook is Fundamentals; it includes heating and cooling calculations. Each volume of the ASHRAE Handbook is updated every four years. The design professional must consult ASHRAE data for the standards of design and care as the typical building codes provide little to no information on HVAC design practices; codes such as the UMC and IMC do include much detail on installation requirements, however. Other useful reference materials include items from SMACNA, ACGIH, and technical trade journals.
I agree that good filtration and a sealed system will prevent the need for duct cleaning. However, when we do get called it is because the duct work has reached a noticeable state of restriction or dust or the homeowner is hyper-sensitive to these pollutants in their home. Most of the time we find that no filter or a cheap (99 cent) filter is being used or they have serious duct leaks in the system. If you are hiring a cleaner make sure they are using professional cleaning equipment which will consist of a rotating brush system and a vacuum source. Be highly skeptical of the contractor with no branded system or the guy who shows up with just chimney brushes and a shop vac. He will not be able to reach around all the corners or all the runs in your system and he will be taking your money for a superficial cleaning at best. Only trust a company that offers VIDEO inspection and more importantly.... a contractor who repairs, installs and seals ducts if a problem is discovered or heaven forbid, created. Good luck and get your ducts sealed if you do have a leak! It is one of the greatest energy losses to a home other than being poorly insulated.

The most effective way to clean air ducts and ventilation systems is to employ Source Removal methods of cleaning. This requires a contractor to place the system under negative pressure, through the use of a specialized, powerful vacuum. While the vacuum draws air through the system, devices are inserted into the ducts to dislodge any debris that might be stuck to interior surfaces. The debris can then travel down the ducts to the vacuum, which removes it from the system and the home.

Without proper ventilation, carbon monoxide can be lethal at concentrations of 1000 ppm (0.1%). However, at several hundred ppm, carbon monoxide exposure induces headaches, fatigue, nausea, and vomiting. Carbon monoxide binds with hemoglobin in the blood, forming carboxyhemoglobin, reducing the blood's ability to transport oxygen. The primary health concerns associated with carbon monoxide exposure are its cardiovascular and neurobehavioral effects. Carbon monoxide can cause atherosclerosis (the hardening of arteries) and can also trigger heart attacks. Neurologically, carbon monoxide exposure reduces hand to eye coordination, vigilance, and continuous performance. It can also affect time discrimination.[15]

Metal is way better than flex duct or ductboard. It gets better airflow, holds up to critters and duct cleaners. I know of no hvac company here that cleans ductwork. (there probably is one somewhere) The mfg's of duct cleaning equipment keep trying to sell us hvac people on their benefits and profit potential but most all hvac people know that unless you have metal ductwork you are NOT doing the customer any favors.

HVAC equipment is estimated to last about 15 to 20 years. Yet over the years, parts go out and need to be repaired. Heat sensors, exchangers, and ducts can become worn out. Air conditioning motors may need repairing from time to time. For repairs to your heating and air conditioning systems, and even general maintenance, let HomeAdvisor help. Enter your zip code and let us connect you with prescreened HVAC repair services near you.