Without proper ventilation, carbon monoxide can be lethal at concentrations of 1000 ppm (0.1%). However, at several hundred ppm, carbon monoxide exposure induces headaches, fatigue, nausea, and vomiting. Carbon monoxide binds with hemoglobin in the blood, forming carboxyhemoglobin, reducing the blood's ability to transport oxygen. The primary health concerns associated with carbon monoxide exposure are its cardiovascular and neurobehavioral effects. Carbon monoxide can cause atherosclerosis (the hardening of arteries) and can also trigger heart attacks. Neurologically, carbon monoxide exposure reduces hand to eye coordination, vigilance, and continuous performance. It can also affect time discrimination.
If your non metal ductwork is that dirty you should just have it replaced AND sealed. Also most duct systems are not very well designed. Look for proper sizing and do not go cheap with one or two intakes (return grills) You need them through-out the house. Here in Austin the duct cleaners are carpet cleaners and chimney swifts. (this is who the duct cleaning equipment mfgs call on when the hvac people do not get on board. They DO clean other types of ductwork and we (the hvac guys) have to fix them. I am not aware of any of these non hvac guys cleaning and servicing the actual equipment. Here in Texas it is against the law for them to do so. Treat the entire house as a system, not just the ductwork and /or hvac equipment. Home performance really does work to increase comfort and air quality while reducing operating costs.
I own an HVAC company. Dirt in your ducts stays there and hurts no one. It is like dirt on the ground outside. This industry was infiltrated by a bunch of money grubbing low lifes years ago. As a credible company, we do not clean air ducts. Some who were credible probably signed on not knowing what else to do or to try to make a buck another way. These companies, because they also do HVAC work not only rip off private homeowners, they are ripping off legitimate HVAC company's customers and the integrity of what can and should as a rule be a great service industry. Some probably have gotten into this to simply offer what competitors who were ripping off their customers were offering. Anyone cleaning ducts is in my opinion raising a big red flag that they cannot and should not be trusted. Political pressure from NADCA, advertising dollars, manufacturers and marketers of duct cleaning equipment, and intense competition for the customers is the only reason the government and adverstising companies have not run them out of business and that this cancer perpetuates itself.
Duct cleaning has never been shown to actually prevent health problems. Neither do studies conclusively demonstrate that particle (e.g., dust) levels in homes increase because of dirty air ducts. This is because much of the dirt in air ducts adheres to duct surfaces and does not necessarily enter the living space. It is important to keep in mind that dirty air ducts are only one of many possible sources of particles that are present in homes. Pollutants that enter the home both from outdoors and indoor activities such as cooking, cleaning, smoking, or just moving around can cause greater exposure to contaminants than dirty air ducts. Moreover, there is no evidence that a light amount of household dust or other particulate matter in air ducts poses any risk to your health.