The three major functions of heating, ventilation, and air conditioning are interrelated, especially with the need to provide thermal comfort and acceptable indoor air quality within reasonable installation, operation, and maintenance costs. HVAC systems can be used in both domestic and commercial environments. HVAC systems can provide ventilation, and maintain pressure relationships between spaces. The means of air delivery and removal from spaces is known as room air distribution.[3]
Some of the research I have done suggests to have your ducts cleaned when you first purchase a new home to remove drywall dust. Maintain your system well and you shouldn't have to do it again until you want to sell. Those are the two times cleaning was suggested. So for peace of mind maybe it is a good idea to do it even if you buy a used home and then maybe every 5-10 years.
I agree that good filtration and a sealed system will prevent the need for duct cleaning. However, when we do get called it is because the duct work has reached a noticeable state of restriction or dust or the homeowner is hyper-sensitive to these pollutants in their home. Most of the time we find that no filter or a cheap (99 cent) filter is being used or they have serious duct leaks in the system. If you are hiring a cleaner make sure they are using professional cleaning equipment which will consist of a rotating brush system and a vacuum source. Be highly skeptical of the contractor with no branded system or the guy who shows up with just chimney brushes and a shop vac. He will not be able to reach around all the corners or all the runs in your system and he will be taking your money for a superficial cleaning at best. Only trust a company that offers VIDEO inspection and more importantly.... a contractor who repairs, installs and seals ducts if a problem is discovered or heaven forbid, created. Good luck and get your ducts sealed if you do have a leak! It is one of the greatest energy losses to a home other than being poorly insulated.
In most modern homes with up-to-date heating and air conditioning systems, filters are changed regularly through the year, so you may not even need to hire a professional. However, keep your eyes open for the accumulation of dust, dirt, dander and mold. If you see it despite regularly changing your filters it could be an indication you need a high-pressure cleaning.

An alternative to packaged systems is the use of separate indoor and outdoor coils in split systems. Split systems are preferred and widely used worldwide except in North America. In North America, split systems are most often seen in residential applications, but they are gaining popularity in small commercial buildings. The split systems are a great choice for small buildings where ductwork is not feasible or where the space conditioning efficiency is of prime concern [20]. The benefits of ductless air conditioning systems include easy installation, no ductwork, greater zonal control, flexibility of control and quiet operation [21]. In space conditioning, the duct losses can account for 30% of energy consumption [22]. The use of minisplit can result in energy savings in space conditioning as there are no losses associated with ducting.
Pro Tips: Before you buy one of the learning thermostats available, you should beware of their shortcomings. First, many require a c-wire to work properly. A common problem is that the old thermostat might not use a c-wire, and this makes it confusing when swapping wires to the new thermostat. Secondly, if you change your thermostat setting often, you might become frustrated with a nest thermostat or other learning thermostat. It will be constantly trying to learn patterns in your random setting changes, and will therefore change your home’s temperature when you don’t want it to. If you have a fairly consistent schedule or don’t mind overriding the unit either manually or via the app on your way home or when leaving, then you won’t experience this issue.
My point is that the brand of equipment you choose is going to affect your HVAC installation cost greatly. People often call us for an air conditioning installation job and say, “I would like to install Carrier equipment.” Now, if you are a future client of ours, I’ll have to warn you – I can be a bit of a smart-ass. Why can’t work be fun? Besides…I was in the Navy for 11 years, what do you expect. 
You should be aware that although a substance may look like mold, a positive determination of whether it is mold or not can be made only by an expert and may require laboratory analysis for final confirmation. For about $50, some microbiology laboratories can tell you whether a sample sent to them on a clear strip of sticky household tape is mold or simply a substance that resembles it.
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