The most effective way to clean air ducts and ventilation systems is to employ Source Removal methods of cleaning. This requires a contractor to place the system under negative pressure, through the use of a specialized, powerful vacuum. While the vacuum draws air through the system, devices are inserted into the ducts to dislodge any debris that might be stuck to interior surfaces. The debris can then travel down the ducts to the vacuum, which removes it from the system and the home.
2. If air quality is so important and duct cleaniliness is so uncertain, why not adopt doubling filtering; that is, in addition to the existing main furnace filter, add a filter at each air outlet. I understand replacing so many filters would be a burden, but air outlets can be designed for easy filter replacement. The builders and home design engineers should bear responsibility to provide good and low maintenance homes, rather than prioritizing on fancy or costly featuers for homes.

I guess I should present my credentials first, I am a 30 year veteran of the heating and cooling industry. I started at the bottom and have participated in every area of the trade. Installer, service, maint. Ownership, rep, territory manager and so on. A forced air duct system is a large vacume. Like your vacume it has an air intake (return air) and an exhaust (supply registers). A filter just like a vacume (located next to furnace or air handler). Now I want you to visualize something. Put your head inside your vacume cleaner and breath. Get the picture? This is what your duct work looks like. Do you clean your vacume when it’s dirty? If it’s full and the filter is dirty you lose performance and it starts poluting the air you breathe. It’s common sense. I recommend hiring a duct cleaning outfit that you have researched to be honest, background checked, drug tested, insured, and highly recommended by your piers in the area. The service is a necessity, but like everything, it should be done by a qualified company.
These factors are included in a "Manual J" calculation. Contractors who make these calculations before recommending a size can take a couple of hours collecting the information and making the calculation. If your contractor doesn't do it, there are services that will do it for around $99. If you're feeling particularly on the ball, there are also free online calculators.
WELL, this summer when I opened them up we had black dust spewing from one of the upstairs vents. It resembled the fuzz that comes off new towels. This prompted us to look into duct cleaning. We heard from someone who had it done several times, said it was worthwhile, and knew of a firm that did a good job. Clean Air America sent a single technician for the appointment and after counting registers and ducts gave me a price of $360.00 which included “sanitizing” the system (a $99 additional fee per can used). The small size of the plenum forced him to connect the 8” round vacuum hose from the truck to the 10” square opening from our humidifier unit. In hindsight, a mistake since it reduced the “negative” pressure in the system.
Without proper ventilation, carbon monoxide can be lethal at concentrations of 1000 ppm (0.1%). However, at several hundred ppm, carbon monoxide exposure induces headaches, fatigue, nausea, and vomiting. Carbon monoxide binds with hemoglobin in the blood, forming carboxyhemoglobin, reducing the blood's ability to transport oxygen. The primary health concerns associated with carbon monoxide exposure are its cardiovascular and neurobehavioral effects. Carbon monoxide can cause atherosclerosis (the hardening of arteries) and can also trigger heart attacks. Neurologically, carbon monoxide exposure reduces hand to eye coordination, vigilance, and continuous performance. It can also affect time discrimination.[15]
Heaters exist for various types of fuel, including solid fuels, liquids, and gases. Another type of heat source is electricity, normally heating ribbons composed of high resistance wire (see Nichrome). This principle is also used for baseboard heaters and portable heaters. Electrical heaters are often used as backup or supplemental heat for heat pump systems.
An energy recovery ventilator: This component helps improve the air inside your home by swapping it out with fresh air from the outside. During the winter months when houses are closed up to keep out the cold, the air inside becomes a handy way for colds and flu to infect an entire family. By circulating outside air inside, the health of your family will have a better chance.

You should be aware that although a substance may look like mold, a positive determination of whether it is mold or not can be made only by an expert and may require laboratory analysis for final confirmation. For about $50, some microbiology laboratories can tell you whether a sample sent to them on a clear strip of sticky household tape is mold or simply a substance that resembles it.