An air conditioner's compressor contains a refrigerant. As it works, it sends this refrigerant through the system. As warm air blows across the coil that carries this refrigerant, the heat transfers to the refrigerant (cool always absorbs warm). A fan moves the cooled air through the ducting and out of vents that lead into the rooms of your house. The refrigerant returns to the compressor where the absorbed heat is moved outside. The refrigerant is then sent through the coil once again to continue the cycle.
Since the 1980s, manufacturers of HVAC equipment have been making an effort to make the systems they manufacture more efficient. This was originally driven by rising energy costs, and has more recently been driven by increased awareness of environmental issues. Additionally, improvements to the HVAC system efficiency can also help increase occupant health and productivity.[23] In the US, the EPA has imposed tighter restrictions over the years. There are several methods for making HVAC systems more efficient.
I called a company name “GREEN RHVAC” with their $29.00 one system air duck cleaning. When the guy came with a truck I asked him to tell me how much he will charge and he said that if he gave me price and I didn’t want the service then he would charge me $89 or he would tell me how much he charge me after he finished the work. I immoderately sense that I made mistake to call him to my house. To cut my lost I asked him to give me the price and it was $1600 for two systems house. I paid $100 to him for my lesson to learn and search online to find this site is very helpfully and I should do it before to call anyone for air duck cleaning.
So, the total price to a contractor for this project is $7,195.77 (Carrier is expensive), which we’ll use to calculate a fair HVAC installation cost. As I said, we typically use 40% in the industry to cover our own personal profit, as well as our insurance and other expenses. Let’s take a look at page three of a Final Report from our own online HVAC calculator, the HVAC Design & Consultation Program.
Important Tip: Don’t just pay attention to the high-end of the price range! – which is what I know you are all looking at, but also look at the low range. If a contractor is cheaper than this, ask “why?” Usually it is because they don’t have liability insurance, workman’s compensation insurance, are unlicensed, all of the above, or worst yet, they don’t use HVAC technicians. You are spending a lot of money.  Make sure that they are licensed (In California, check here at CSLB License Checker) and insured.

It’s 11 years plus in the industry I have only had to sanitize two systems both were slab systems that were in concrete and could be cleaned with a different method than normal duct cleaning. We were able to use water to rinse out the disinfectant. Would you use a chemical on anything else you use to eat or drink with and not rinse it off? The ducts in your home should be thought of as your homes heart and lungs and breathe the same air that you do. And just like us we wouldn’t use bad chemicals in our lungs and heart.
R-22 Freon is being phased out & isn't readily available. So the service company may only purchase as needed and the lack of availability would make their cost high. But, as long as they can get it, whatever the cost, unfortunately, is less expensive than replacing the A/C. Which will be the case eventually since it's no longer manufactured or sooner as in my case with a not so old a/c that sprang a leak, that would have been just a repair, but since it uses R-22 the whole unit has to be upgraded(replaced).  
Here in Atlanta we get 6 to 10 $49 coupons in the mail weekly…I have always consider them a complete scam….just had my master bathroom& bedroom and guest bath completely remodeled down to the studs…Had my 3 returns nearest the area sealed to prevent sheet rock dust to spread…it worked and I personally cleaned all 7 returns when a 5 HP , new Rigid shop Vac($99 from HD)…took one hour and I found little evidence that “I need my ducts cleaned” Had quotes from $400 to $600…I use the best air filters for my air handler and change it every 2 to 3 months…..any dust is trapped in it and I believe the Air Duct folks are all cons….
I need a complete system replacement , before I was trying to get an evaporator coil replaced , of course the price is between $2200 an $2800 , then get told it probably will over tax my ac unit within months , so now and like everyone else what do you buy 14 ,15 16 17 seer units ,price and how do we know its reasonable  why can't there be '" a estimated price ,in the ball park, a range of prices ,so we can at least go from their .....  Now it's from 7500 to 15000. Frustrating  from the start so everybody good LUCK.   Draw a # from the hat    Unregulated  and who do you BELIEVE, just like on NCIS go with your gut feelin   

Ventilation is the process of changing or replacing air in any space to control temperature or remove any combination of moisture, odors, smoke, heat, dust, airborne bacteria, or carbon dioxide, and to replenish oxygen. Ventilation includes both the exchange of air with the outside as well as circulation of air within the building. It is one of the most important factors for maintaining acceptable indoor air quality in buildings. Methods for ventilating a building may be divided into mechanical/forced and natural types.[16]

Air conditioning units are prone to the pitfalls of wear and tear. You can prolong this, however, with proper maintenance procedures. Without regular maintenance even an immaculate AC installation in Fort Smith, Arkansas cannot guarantee performance. Our maintenance service is thorough, leaving no area unattended. If there’s a problem, we’ll catch it early and prevent avoidable breakdowns and costly repairs.
I even asked if this is something they don't do, as in services on a Saturday night.  I was told by the receptionist that they do and I would just be ok calling another company if they is not  part of their services. They again assured me someone WILL call me in 10 mins.  Well, unless their definition of 10 mins is never, then they got it wrong as I am still waiting to be called 5 days later.

You may consider having your air ducts cleaned simply because it seems logical that air ducts will get dirty over time and should be occasionally cleaned. Provided that the cleaning is done properly, no evidence suggests that such cleaning would be detrimental. EPA does not recommend that the air ducts be cleaned routinely, but only as needed. EPA does, however, recommend that if you have a fuel burning furnace, stove or fireplace, they be inspected for proper functioning and serviced before each heating season to protect against carbon monoxide poisoning.