I’m a heating and air conditioning contractor. I’ve been in the trade for over 15 years. I’ve witnessed numerous duct cleaning projects and talked with many duct cleaners. Duct cleaning as it’s usually promoted is a fraud. Most duct cleaners claim to deliver cleaner air. They deliver exactly the opposite. The studies on duct cleaning prove it, including a May 1998 study sponsored by NADCA and the EPA! The stories are compelling, but they can come up with stories that “prove” anything they want. Internet searches are dominated by results from those who are paid to tell you that duct cleaning is worthwhile. Search a little more and you’ll find the truth.

Be careful with HVAC change-outs.  Change-outs are only about 15-20% of the HVAC installation industry. Decrease HVAC installation cost by investing in new ductwork now if needed. Your ducts wear out too, and make sure that your ducts are in fantastic shape if you do this. Many contractors push this because it’s easy and cheap for them, with good pay-off. Do your research and replace them if you need to in order to avoid doing it later, as well as avoid potential health hazards from using old, broken ductwork.
Is duct cleaning worth it? There is not a yes or no answer that suits everyone. On an Air Force base, the system was not air tight and there was leakage around the filters. The system got dirty. A professional company was called out. The Duct was big enough that a technician could go inside the metal duct and clean it. There was a new Air Handler installed and things were sealed up better. in this case it was worth it.
Do you live in a historic home and want to tie your new system in to work with existing features? The price will go up to do the job right. All of these things add up to slow down the HVAC company, which takes more time, which costs more money for labor and parts. This is especially true if they are a legitimate company which is licensed, bonded and insured. Simply put, this is the “X-Factor” in your HVAC installation cost. Again, you could get people to do it for cheaper…but you won’t be happy with the results, I promise.
The average cost of keeping your residential ductwork orderly is going to vary greatly from that of a commercial building. This is because commercial air ducts are often larger and more extensive. Residential cleanings can cost an average of about $20-$30 per vent. For commercial buildings, service providers must do an estimate of your space before they can provide an accurate quote. Before factoring in the materials and the number A/C and furnace units, you can expect a commercial project to cost at least $35-$50 per hour.

Demonstrate visible evidence of microbial growth in your duct work. Some service providers may attempt to convince you that your air ducts are contaminated by demonstrating that the microorganisms found in your home grow on a settling plate (i.e., petri dish). This is inappropriate. Some microorganisms are always present in the air, and some growth on a settling plate is normal. As noted earlier, only an expert can positively identify a substance as biological growth and lab analysis may be required for final confirmation. Other testing methods are not reliable.
I even asked if this is something they don't do, as in services on a Saturday night.  I was told by the receptionist that they do and I would just be ok calling another company if they is not  part of their services. They again assured me someone WILL call me in 10 mins.  Well, unless their definition of 10 mins is never, then they got it wrong as I am still waiting to be called 5 days later.
I to had an odd layer of white'ish dust building up especially during seasonal periods when the HVAC ran a a lot. I carefully swept up the fine dust into a small pile and had it analyzed. Turns out it was very fine fiberglass powder dust. It turns out it is the insulation form the attic! (My attic has blown in insulation). Turns out if you (I) had small gaps around my HVAC registers in the ceiling whee the airs blows into the room. What occurred in my case was that the exiting air at that seam creates a vacuum effect at the grate vent cover and draws and then blows fine insulation dust from the attic into the house. Removing each register grate and sealing each tin outlet gap with calking between the dry wall ceiling and tin fixed the issue. A couple were so bad with bowed gaps I had to screw down the bowed tin to the attaching stud better. Checking the very same glass top desk that catches and shows any dust accumulation now shows only very small amounts of normal house dust build up over several weeks. A big, big improvement. You might have a look by simply removing a couple vent covers yourself.
I thought the price advertised at 129.95 for duct cleaning was great and called to clean our ducts. When they came in to do the the job I could not be home and my wife dealt with them. My wife ended up paying 954.00. They convinced my wife that there was 1.5 inches of mold built up on the Evaporators and coils. It is not the money, my wife could not go to the basement to witness the mold build up or the coil fouling. We have not cleaned our ducts for at least 10 years. The last price we paid for our duct cleaning was 150.00. My concern is that they told my wife not to turn on the heat for 2 hours due the strong chemicals they used to kill the mold. Are these chemicals approved as safe?
In addition, the black dust was found in most of the heat registers. He could rub it off on his fingers but did nothing but spray compressed air on it which didn’t make it disappear since it wasn’t loose. Also, in the register in the basement he described the black dust as being oily. The reality of that situation is that I had the AC on until the morning of the service and minutes after he snaked the hoses in my back door it started raining. The basement register had condensation from the humidity all over it. It was not oily but wet. He asked for an old towel and wiped it out. Never saw anything so black – because I never had to clean soot. That is what I have in my ducts. Soot from years of the old coal furnace.

I originally took off one star because of the SNAFU with getting the part ordered.  When Alberto called me on the phone he admitted the person had "gotten busy with other things" and apologized.  THAT was taking the high road and I was impressed by that.  Sadly, for reasons I won't guess at, Alberto has decided to take the low road in his comments and imply that they got the part as quickly as possible.  Well, we called at 2:30 so did someone spend six and a half hours finding the part??  That seems very doubtful.
All of the products discussed above are registered solely for the purpose of sanitizing the smooth surfaces of unlined (bare) sheet metal ducts. No products are currently registered as biocides for use on fiber glass duct board or fiber glass lined ducts, so it is important to determine if sections of your system contain these materials before permitting the application of any biocide.
Heating, ventilation, and air conditioning (HVAC) systems have been shown to act as a collection source for a variety of contaminants that have the potential to affect health, such as mold, fungi, bacteria, and very small particles of dust. The removal of such contaminants from the HVAC system and home should be considered as one component in an overall plan to improve indoor air quality.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.