yes get a good company and pay the price, I found so much dust and dirt and wood and paint chips and bugs and even bottle caps in my ductwork. I hired a major plumbing company who cleaned ductwork and i will say they did an excellent job cleaning my vent. they did miss one point in my ductwork because i still started to see dust all over my furniture and i realized that my retunduct work that was connected with a piece of sheet metal beam which was 16" across , the contractor that built my condo used a 16" wide sheet of sheet metal to connect the vent system to my return for the air to return back into my condo. The contractor should have built a 8" x16" square duct by 6 feet long to connect my intake to my return instead of using a sheet of sheet metal 16" wide by using two 3' sections by 16 inches wide. That was a shor cut which caused a major problem fir me.
Many homes have a forced-air HVAC system. Both the heating and the central air conditioning units share a ductwork system where they either push in or pull out warm or cooled air. There are also heating and cooling systems that don’t require ductwork — such as ductless mini-splits — but work on the same principles of heat exchange. The national average to hire an HVAC specialist is $2,920-$3,670, with costs varying depending on the work you need done and the equipment you are installing.
A small number of products are currently registered by EPA specifically for use on the inside of bare sheet metal air ducts. A number of products are also registered for use as sanitizers on hard surfaces, which could include the interior of bare sheet metal ducts. While many such products may be used legally inside of unlined ducts if all label directions are followed, some of the directions on the label may be inappropriate for use in ducts. For example, if the directions indicate "rinse with water", the added moisture could stimulate mold growth.
Once on the scene, trained Sears professionals utilize powerful, truck-mounted equipment to clear your air ducts of dust, debris, pet dander, allergens, and grime. Our powerful air duct cleaning suction equipment vacuums out years of accumulated dust from your air ducts, leaving them clean and clear. Once finished, our technicians remove all equipment and make sure that your ducts and HVAC unit are restored to their best condition. For continued protection against dirty air ducts, your service technician may suggest a variety of air purification products.

Some of these components can be repaired or replaced by the homeowner, such as filters, fuses, and clogged up drain lines. Coils, compressors and the other components are best left to a professional. In some cases, you may have a system that is so old that parts are no longer available or else they aren't up to code. In this case you will have to consider replacing the entire system.
Just had my air ducts cleaned. They used a high pressure air hose in all the heat ducts and cold air returns. He showed me the stuff that came out, the reason for the duct cleaning was the fact that I had a problem. With rodents. There was quite a few mummified rats and mice, and he said I wouldn’t have to have them done again unless I incur another problem or have renovations done. Cost me 345.00 for a 2 storey large old home. Not a bad price as I had them done when I moved in 28 years ago and it cost me 500.00. Lots of dog hair, toys, balls and assorted goodies came out as well. Took them 2 hours. I did have sanitizer put in the ducts because of the dead rodents.
My Carrier furnace occasionally (one-two times a day) does not start. It shows error code 15 ("BLOWER MOTOR LOCKOUT -This status code indicates the blower failed to reach 250 RPM or the blower failed to communicate to the variable speed furnace control within 30 seconds after being turned ON in two successive heating cycles."). However, when I turn off and on the furnace power switch it starts and runs fine for a while. Sometimes it runs fine all day, but does not start only once in the evening or in the night. It is 13 years old I was thinking to replace whole thing if repair cost is too high. But I am not ready to pay $10,000. 
Be careful of dishonest HVAC contractors. There’s no magical formula to see if an HVAC contractor is scamming you, unfortunately, but remember that they typically do this in one of two ways: first, they are charging grossly low prices (far below everyone else), or second, they aren’t including what everyone else is. In the first situation, they will charge you change fees, other hidden fees, or they stole the equipment and are passing themselves off as legitimate contractors (very common in California these days). In the second situation, they are charging you a very fair price, but aren’t including what the other contractors are (i.e. charging $10,500 for the installation which is fair, but not including the ductwork which is a scam unless there is some other, complex stuff going on there).
You may consider having your air ducts cleaned simply because it seems logical that air ducts will get dirty over time and should be occasionally cleaned. Provided that the cleaning is done properly, no evidence suggests that such cleaning would be detrimental. EPA does not recommend that the air ducts be cleaned routinely, but only as needed. EPA does, however, recommend that if you have a fuel burning furnace, stove or fireplace, they be inspected for proper functioning and serviced before each heating season to protect against carbon monoxide poisoning.
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