If you want to get some of the dust and debris out of your ventilation system, you can mix household cleaners like bleach with water, dip a cloth in the mix and then the wipe out the system. This will remove a layer of the spores, which could increase the quality of air a bit and help with the flow of air throughout the house until a pro can come out.
These are the prices for a proper installation from a professional – as a word to the wise, HVAC systems require fine tuning and the custom fabrication of parts during installation to work properly, otherwise they will likely fail prematurely. But there are plenty of people who will do it for cheaper than this, using substandard, used, or stolen equipment (stolen from construction sites and new housing developments). Or, they are using unskilled laborers with no experience, etc. But HVAC is not a “we’ll figure it out trade;” there is a right way and a wrong way to do things. There are just too many predatory companies out there, so be careful. I’d highly recommend not skimping on your HVAC contractor. If you go cheap, you will typically pay more in the long run...and in California, that will be a lot!
Dehumidification (air drying) in an air conditioning system is provided by the evaporator. Since the evaporator operates at a temperature below the dew point, moisture in the air condenses on the evaporator coil tubes. This moisture is collected at the bottom of the evaporator in a pan and removed by piping to a central drain or onto the ground outside.

Ok what you said is true but in most cases ducts are in a duct flex format, and knowing that the dust in people's flex duct is just surface dust, any real debris that are in the duct itself will result in very little to no air flow which will keep your unit from performing properly, but if it is true allergy reasons then replacing your duct system is better for overall better air quality, plus if you do pay attention to the warranty on flexible duct is that it only has a 10 year warranty and typically only lasts for 20 years so do your research before having a duct cleaning, and to add one more thing if your duct work is completely metal and you can't see visible insulation then your duct on the inside has insulation inside of it, if you replace that with duct work that is clean metal on the inside and wrapped with insulation on the outside then it will further reduce the air bourne fiberglass and dust.
Fast forward 1 year and 1 week and the circuit board that HVAC Service had installed has failed again. They came out and said that it failed from water condensation dripping onto it, so we needed to replace it and reroute the pipes to prevent future water damage.  That would cost double what I paid last year.  Why didn't they fix the problem last year at the initial repair instead of putting in a circuit board that was bound to fail again?!? They were strongly recommending that the furnace be completely replace for a huge fee to avoid the same thing happening again.  I paid $59 for them to tell me they didn't fix it right last year. This didn't feel right, so I sought a second opinion.
I to had an odd layer of white'ish dust building up especially during seasonal periods when the HVAC ran a a lot. I carefully swept up the fine dust into a small pile and had it analyzed. Turns out it was very fine fiberglass powder dust. It turns out it is the insulation form the attic! (My attic has blown in insulation). Turns out if you (I) had small gaps around my HVAC registers in the ceiling whee the airs blows into the room. What occurred in my case was that the exiting air at that seam creates a vacuum effect at the grate vent cover and draws and then blows fine insulation dust from the attic into the house. Removing each register grate and sealing each tin outlet gap with calking between the dry wall ceiling and tin fixed the issue. A couple were so bad with bowed gaps I had to screw down the bowed tin to the attaching stud better. Checking the very same glass top desk that catches and shows any dust accumulation now shows only very small amounts of normal house dust build up over several weeks. A big, big improvement. You might have a look by simply removing a couple vent covers yourself.
PickHVAC Tips: Electricity resistance heat is the most expensive heating type. You don’t want one of these unless you’re heating less than 30 days per year. The upfront cost of an electric furnace is much lower than the cost of a gas furnace. However, operating costs are two to three times higher. If winters are cold where you live, you’ll waste your upfront cost savings in just a few years of high electric bills.
The jury is out on whether or not cleaning your air ducts and vents has a significant enough impact to be necessary. A proven connection between immaculate duct systems and air quality in the home has not been made. However, if your vents display any of the signs listed above, cleaning would certainly be in your best interest. Allowing mold, debris and bacteria to fester could create bigger problems down the line. If having your system disinfected is within your budget, you may prefer to take care of these issues rather than ignore them.
On average, we (Indians in Ontario) receive 3-5 calls per day for duct cleaning services from India. I did get ducts cleaned twice in 25 years. For a newly built house, it should be done as material goes into the ducts. Every year, before turning the heat on, I clean the ducts, using the vacuum pipe or with wet towel. Most of the dust, pet hair, small items get to the ducts from the top floors, not where system is installed. Even in winter months, I open 2-3 windows for air circulation for 15 minutes, specially right after cooking, almost daily. We breath in the same stale air, develop health issues. Also, I have an added air cleaning and fileration system installed. At a low rate, this system constantly cleans the inside air and also that it pulls from the outside. Duct cleaning is a scam, there are other efficient and cost effective methods we can use to purify the inside air.

CIBSE publishes several guides to HVAC design relevant to the UK market, and also the Republic of Ireland, Australia, New Zealand and Hong Kong. These guides include various recommended design criteria and standards, some of which are cited within the UK building regulations, and therefore form a legislative requirement for major building services works. The main guides are:
In some older homes, there was a grey Mylar flexible duct. After years of use, it started to decompose. A duct cleaning company can come out and find why your air is so dirty and why your building doesn’t heat or cool like it used to. This is a savings on your part. You could also be sucking in Hot, dirty attic air. However, sometimes when a duct cleaning company comes out to clean it, the old duct can be destroyed and have to be replaced. Someone with little experience can replace this ductwork but if it isn’t done right it can ruin a lot of things and cost a lot in repairs.
I think that the coding and permit industry is a joke!! They will not allow the homeowner to apply for the permit it has to be the licenced contractor. It would make since to allow the homeowner to apply for this. But it is all about money!! They really don't care if its up to code because if they did then they wouldnt care who applied and payeed for it, but they want the contractor to do it so if they do something wrong they can fine them instead of just pointing it out and allowing them to do it right.
So HVAC sent Tony Diaz to my house. I was at work so he was subjected to the most excruciatingly exacting woman on the planet (my wife). Tony impressed her with his friendliness, professionalism and the obvious jouneyman-level knowledge of his craft. He found literally --burnt-out-- parts in our system and replaced them. It cost us a bit but I know enough about the parts to see there was no gouging on the parts and a fair rate for the labor. It wasn't cheap but it was fair and worth every dime.

One of the best ways to know if your ducts or vents need to be cleaned is to just check them. Your eyes will be able to check for indications of mold, dust or pollen buildup. You might also be able to smell the presence of mold, which would be a clear indicator. Ductwork will have some buildup of dust, since the return registrars pull air back in. However, this doesn't mean your ducts have too much debris, and you can easily clean them with a duster or vacuum.

So, the total price to a contractor for this project is $7,195.77 (Carrier is expensive), which we’ll use to calculate a fair HVAC installation cost. As I said, we typically use 40% in the industry to cover our own personal profit, as well as our insurance and other expenses. Let’s take a look at page three of a Final Report from our own online HVAC calculator, the HVAC Design & Consultation Program.
I just had my blower module replaced because my AC coil was frozen over. The underside of my coils had a thick mat of dust because I had never had it cleaned. I cleaned it myself by using a soft brush attachement on a shop vac. The inside of the blower appears to have a white/green growth, and I am sure the ductwork of my 30 year old house can’t be in good condition.

The original furnace was a coal fired “octopus” design which had no blower to circulate the air but relied upon warm air rising to distribute the heat. That also means that the system breathed air in from the basement and most of this type did not have a cold air return system. At some point (probably in the 1940’s) the system was upgraded to a forced air gas furnace. The upgrade included replacing the 12″ diameter air ducts exposed in the basement with 6″ ducts and a cold air return system of ducts from the two (only two) air returns on the first floor.
Although HVAC is executed in individual buildings or other enclosed spaces (like NORAD's underground headquarters), the equipment involved is in some cases an extension of a larger district heating (DH) or district cooling (DC) network, or a combined DHC network. In such cases, the operating and maintenance aspects are simplified and metering becomes necessary to bill for the energy that is consumed, and in some cases energy that is returned to the larger system. For example, at a given time one building may be utilizing chilled water for air conditioning and the warm water it returns may be used in another building for heating, or for the overall heating-portion of the DHC network (likely with energy added to boost the temperature).[4][5][6]

EPA does not recommend that air ducts be cleaned except on an as-needed basis because of the continuing uncertainty about the benefits of duct cleaning under most circumstances. EPA does, however, recommend that if you have a fuel burning furnace, stove, or fireplace, they be inspected for proper functioning and serviced before each heating season to protect against carbon monoxide poisoning. Some research also suggests that cleaning dirty cooling coils, fans and heat exchangers can improve the efficiency of heating and cooling systems. However, little evidence exists to indicate that simply cleaning the duct system will increase your system's efficiency.

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