In most modern homes with up-to-date heating and air conditioning systems, filters are changed regularly through the year, so you may not even need to hire a professional. However, keep your eyes open for the accumulation of dust, dirt, dander and mold. If you see it despite regularly changing your filters it could be an indication you need a high-pressure cleaning.
The jury is out on whether or not cleaning your air ducts and vents has a significant enough impact to be necessary. A proven connection between immaculate duct systems and air quality in the home has not been made. However, if your vents display any of the signs listed above, cleaning would certainly be in your best interest. Allowing mold, debris and bacteria to fester could create bigger problems down the line. If having your system disinfected is within your budget, you may prefer to take care of these issues rather than ignore them.
Your contractor will do a load calculation to determine the proper central air conditioning unit for your home. This calculation accounts for the climate, size, shape and orientation of your home, as well as its square footage. A professional will also look at the insulation, windows, walls, floors and other materials that compose your home. He/she will then examine any leaks, seals and existing ducts or vents.