I am NADCA Certified Air Systems Cleaning Specialist. Over the year I have learned on simple answer to this questions: there air duct cleaners and there are pretenders. There will be no benefit at all if you use on the very cheap pretender because they will not really clean anything. On the other hand if you call a qualified air duct cleaner with a NADCA Certification you will, like 99% of my customers, report improvement with your respiratory problems, you will see less dust and the job will pay for itself with energy savings and repair prevention.
Stick with a maximum of 16 SEER units in most cases. Like I said above, contractors push higher SEER units because they make more money, but these units can be expensive at this stage of development, and can drive up your HVAC installation cost. 21 SEER units run about twice the price of a 14 SEER unit, so unless you live in a desert and plan on being there for 30 more years... Likewise, a 16 SEER unit typically costs only about $600-$1,000 more than a 14 SEER, and will usually pay for itself over the lifetime of the unit.
Indoor Coil -- The indoor coil is a heat transfer device. It absorbs the heat from the inside of the house and passes it on to the refrigerant and is pumped outside. Dust that builds up on the coil can hamper its ability to absorb heat. High heat transference coils use very thin metal. Airborne chemicals can cause corrosion which leads to leaks. The constant vibration of the compressor can also cause solder joints to weaken and leak. An indoor coil may operate for weeks with a tiny leak, and you may not notice the loss in performance right away. As soon as a leak is made known, it should be replaced or repaired immediately.