An important component of natural ventilation is air change rate or air changes per hour: the hourly rate of ventilation divided by the volume of the space. For example, six air changes per hour means an amount of new air, equal to the volume of the space, is added every ten minutes. For human comfort, a minimum of four air changes per hour is typical, though warehouses might have only two. Too high of an air change rate may be uncomfortable, akin to a wind tunnel which have thousands of changes per hour. The highest air change rates are for crowded spaces, bars, night clubs, commercial kitchens at around 30 to 50 air changes per hour.[17]

I recently replaced my 44 year old furnace. Over the years we have had several construction projects inside the home. For many years breathing the heated air from the duct work caused excessive sneezing, sinus issues, and lung irritation. . The heat smelled like dust. To maximize air quality I added a humidifier, MERV-11 filter, and UV light onto the new furnace. To further improve air quality, I had the ducts cleaned and sanitized. I took before and after pictures of the inside of each return and output duct. They were filthy before, and sparkling clean and fresh after the procedure. Now when running the system, clean sanitized air flows through my whole house. A huge difference. It will make sleeping and being indoors during the winter months far more tolerable. I use window air conditioners, and run the system in the summer to keep the house air clean and fresh on hot summer days too. It works! Great decision!

We moved to a house built in 1965 from a 1915 house with a dirt basement. Against what I anticipated, the 1965 house was much dustier. It was like felt on top of everything. I cleaned and cleaned and it did become less dusty over time. We then found out a cat lady with over 2 dozen cats lived in the house in the past. We then had to get our furnace replaced and I was able to look down some of the duct work, the dirt and debris was 3-5 inches deep. Additionally, the basement ducts were entirely plugged with debris including dirt, seeds, ants, toys, etc. I had already removed what I could from those. We had our ducts cleaned last year, and the dust in the house is greatly reduced. Also have lost the runny nose I got after moving here. There are duct cleaning con artists out there, but ours did a good job.
Vinick calls air duct cleaning an essential part of home maintenance, akin to mopping and vacuuming. "It’s like changing the oil in your car,” he says. “If you don’t change the oil, you’re going to have a problem. When your components are loaded up with debris, the system has to work harder. When you remove that debris, you get energy consumption savings.”
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Pro HVAC company Southern Comfort Mechanical says on its blog, “If there’s mold growth inside the handler due to excess moisture, algae in the condenser drain line or a dirty evaporator coil, it can negatively impact your AC unit’s efficiency. The filters inside may also build up excess dirt and become clogged, which will also make your AC [or heat pump] waste energy trying to sustain the cool climate inside your home.” These issues are easy to solve. They don’t require replacing the air handler.
Pro Tips: Before you buy one of the learning thermostats available, you should beware of their shortcomings. First, many require a c-wire to work properly. A common problem is that the old thermostat might not use a c-wire, and this makes it confusing when swapping wires to the new thermostat. Secondly, if you change your thermostat setting often, you might become frustrated with a nest thermostat or other learning thermostat. It will be constantly trying to learn patterns in your random setting changes, and will therefore change your home’s temperature when you don’t want it to. If you have a fairly consistent schedule or don’t mind overriding the unit either manually or via the app on your way home or when leaving, then you won’t experience this issue.
Be careful with HVAC change-outs.  Change-outs are only about 15-20% of the HVAC installation industry. Decrease HVAC installation cost by investing in new ductwork now if needed. Your ducts wear out too, and make sure that your ducts are in fantastic shape if you do this. Many contractors push this because it’s easy and cheap for them, with good pay-off. Do your research and replace them if you need to in order to avoid doing it later, as well as avoid potential health hazards from using old, broken ductwork.

R-22 Freon is being phased out & isn't readily available. So the service company may only purchase as needed and the lack of availability would make their cost high. But, as long as they can get it, whatever the cost, unfortunately, is less expensive than replacing the A/C. Which will be the case eventually since it's no longer manufactured or sooner as in my case with a not so old a/c that sprang a leak, that would have been just a repair, but since it uses R-22 the whole unit has to be upgraded(replaced).  
You've probably noticed many appliances boasting an Energy Star Certification. What this means is that manufacturer voluntarily built the product to help reduce greenhouse gases and meet non-regulatory guidelines offered by the Environmental Protection Agency. To earn an Energy Star rating, a product or system must be tested by a third party that has been recognized by the EPA for meeting their testing qualifications.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.